CCL23

CCL23
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	1G91
Identifiants
Aliases	CCL23
IDs externes	OMIM: 602494 MGI: 98263 HomoloGene: 89167 GeneCards: CCL23
Position du gène (Homme)
Chr.	Chromosome 17 humain
Fin	36,017,972 bp
Position du gène (Souris)
Chr.	Chromosome 11 (souris)
Fin	83,483,913 bp
Expression génétique
	Fortement exprimé dans
	poumon droit; ; upper lobe of left lung; ; appendice iléo-cæcal; ; left uterine tube; ; rate; ; rectum; ; endocol; ; muqueuse gastrique; ; muscle lisse; ; Myomètre;
	Fortement exprimé dans
	crypt of lieberkuhn of small intestine; ; Cellule de Paneth; ; lobe pulmonaire droit; ; left colon; ; iléon; ; sang; ; Jéjunum; ; duodénum; ; col de l'utérus; ; muscle intercostal;
	Plus de données d'expression de référence
	n/a
Gene Ontology
Fonction moléculaire	cytokine activity; heparin binding; chemokine activity; CCR1 chemokine receptor binding; CCR chemokine receptor binding;
Composant cellulaire	région extracellulaire; milieu extracellulaire;
Processus biologique	G protein-coupled receptor signaling pathway; monocyte chemotaxis; chemokine-mediated signaling pathway; cell-cell signaling; cellular response to tumor necrosis factor; cellular calcium ion homeostasis; neutrophil chemotaxis; chimiotaxie; negative regulation of C-C chemokine binding; positive regulation of GTPase activity; réponse immunitaire; cellular response to interleukin-1; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; lymphocyte chemotaxis; transduction de signal; negative regulation of cell population proliferation; réponse inflammatoire; regulation of signaling receptor activity; eosinophil chemotaxis;
	Sources:Amigo / QuickGO
Orthologues
	6368
	20305
	ENSG00000276114; ENSG00000274736
	ENSMUSG00000018927
	P55773
	P27784
	NM_005064; NM_145898
	NM_009139
	NP_005055; NP_665905
	NP_033165
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le CCL23 (pour « Chemokine (C-C motif) ligand 23 »), appelé aussi β8‐1 (Ckβ8‐1), MPIF‐1 pour « myeloid progenitor inhibitory factor 1 » ou MIP‐3 pour « macrophage inflammatory protein 3 », est une chimiokine. Son gène est CCL23 situé sur le chromosome 17 humain.

Rôles[modifier | modifier le code]

Il se lie au CCR1^[5] et permet l'attraction des polynucléaires neutrophiles, des monocytes et des lymphocytes^[6]. Il inhibe la prolifération de certaines cellules souches hématopoïétique^[7].

Il jouerait un rôle dans la genèse de l'athérome^[8] et dans l'angiogenèse par l'intermédiaire d'une augmentation de l'expression de la métalloprotéinase matricielle 2^[9] et de la voie du KDR/Flk-1^[10].

En médecine[modifier | modifier le code]

Son taux sanguin est augmenté dans la polyarthrite rhumatoïde^[11], dans la sclérodermie^[12] ainsi que lors d'un accident vasculaire cérébral^[13].

Notes et références[modifier | modifier le code]

↑ ^{a b et c} ENSG00000274736 GRCh38: Ensembl release 89: ENSG00000276114, ENSG00000274736 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000018927 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Youn BS, Zhang SM, Broxmeyer HE et al. Characterization of CKbeta8 and CKbeta8‐1: two alternatively spliced forms of human beta‐chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1, Blood, 1998;91;3118–26
↑ Kim J, Kim YS, Ko J, CK beta 8/CCL23 induces cell migration via the Gi/Go protein/PLC/PKC delta/NF‐kappa B and is involved in inflammatory responses, Life Sci, 2010;86:300–8
↑ Patel VP, Kreider BL, Li Y et al. Molecular and functional characterization of two novel human C‐C chemokines as inhibitors of two distinct classes of myeloid progenitors, J Exp Med, 1997;185:1163–72
↑ Kim CS, Kang JH, Cho HR et al. Potential involvement of CCL23 in atherosclerotic lesion formation/progression by the enhancement of chemotaxis, adhesion molecule expression, and MMP‐2 release from monocytes, Inflamm Res, 2011;60:889–95
↑ Son K‐N, Hwang J, Kwon BS, Kim J, Human CC chemokine CCL23 enhances expression of matrix metalloproteinase‐2 and invasion of vascular endothelial cells, Biochem Biophys Res Commun, 2006;340:498–504
↑ Han KY, Kim CW, Lee TH, Son Y, Kim J, CCL23 up‐regulates expression of KDR/Flk‐1 and potentiates VEGF‐induced proliferation and migration of human endothelial cells, Biochem Biophys Res Commun, 2009;382:124–8
↑ Rioja I, Hughes FJ, Sharp CH et al. Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony‐stimulating factor, Arthritis Rheum, 2008;58:2257–67
↑ Yanaba K, Yoshizaki A, Muroi E et al. Serum CCL23 levels are increased in patients with systemic sclerosis, Arch Dermatol Res, 2011;303:29–34
↑ Simats A, García‐Berrocoso T, Penalba A et al. CCL23: a new CC chemokine involved in human brain damage, J Int Med, 2018;283: 461-475

[refGRCh38Ensembl-1] {a b et c} ENSG00000274736 GRCh38: Ensembl release 89: ENSG00000276114, ENSG00000274736 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000018927 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Youn_1998-5] Youn BS, Zhang SM, Broxmeyer HE et al. Characterization of CKbeta8 and CKbeta8‐1: two alternatively spliced forms of human beta‐chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1, Blood, 1998;91;3118–26

[Kim_2010-6] Kim J, Kim YS, Ko J, CK beta 8/CCL23 induces cell migration via the Gi/Go protein/PLC/PKC delta/NF‐kappa B and is involved in inflammatory responses, Life Sci, 2010;86:300–8

[Patel_1997-7] Patel VP, Kreider BL, Li Y et al. Molecular and functional characterization of two novel human C‐C chemokines as inhibitors of two distinct classes of myeloid progenitors, J Exp Med, 1997;185:1163–72

[Kim_2011-8] Kim CS, Kang JH, Cho HR et al. Potential involvement of CCL23 in atherosclerotic lesion formation/progression by the enhancement of chemotaxis, adhesion molecule expression, and MMP‐2 release from monocytes, Inflamm Res, 2011;60:889–95

[Son_2006-9] Son K‐N, Hwang J, Kwon BS, Kim J, Human CC chemokine CCL23 enhances expression of matrix metalloproteinase‐2 and invasion of vascular endothelial cells, Biochem Biophys Res Commun, 2006;340:498–504

[Han_2009-10] Han KY, Kim CW, Lee TH, Son Y, Kim J, CCL23 up‐regulates expression of KDR/Flk‐1 and potentiates VEGF‐induced proliferation and migration of human endothelial cells, Biochem Biophys Res Commun, 2009;382:124–8

[Rioja_2008-11] Rioja I, Hughes FJ, Sharp CH et al. Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony‐stimulating factor, Arthritis Rheum, 2008;58:2257–67

[Yanaba_2011-12] Yanaba K, Yoshizaki A, Muroi E et al. Serum CCL23 levels are increased in patients with systemic sclerosis, Arch Dermatol Res, 2011;303:29–34

[Simats_2018-13] Simats A, García‐Berrocoso T, Penalba A et al. CCL23: a new CC chemokine involved in human brain damage, J Int Med, 2018;283: 461-475

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